Attachment of rod-like (BAR) proteins and membrane shape.
Mini Rev Med Chem
; 11(4): 272-82, 2011 Apr.
Article
in En
| MEDLINE
| ID: mdl-21428902
ABSTRACT
Previous studies have shown that cellular function depends on rod-like membrane proteins, among them Bin/Amphiphysin/Rvs (BAR) proteins may curve the membrane leading to physiologically important membrane invaginations and membrane protrusions. The membrane shaping induced by BAR proteins has a major role in various biological processes such as cell motility and cell growth. Different models of binding of BAR domains to the lipid bilayer are described. The binding includes hydrophobic insertion loops and electrostatic interactions between basic amino acids at the concave region of the BAR domain and negatively charged lipids. To shed light on the elusive binding dynamics, a novel experiment is proposed to expand the technique of single-molecule AFM for the traction of binding energy of a single BAR domain.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Lipid Bilayers
/
Membrane Proteins
Language:
En
Journal:
Mini Rev Med Chem
Journal subject:
QUIMICA
Year:
2011
Document type:
Article
Affiliation country:
Eslovenia