The expanding roles of the ghrelin-gene derived peptide obestatin in health and disease.
Mol Cell Endocrinol
; 340(1): 111-7, 2011 Jun 20.
Article
in En
| MEDLINE
| ID: mdl-21459124
ABSTRACT
Obestatin is a 23 amino acid, ghrelin gene-derived peptide hormone produced in the stomach and a range of other tissues throughout the body. While it was initially reported that obestatin opposed the actions of ghrelin with regards to appetite and food intake, it is now clear that obestatin is not an endogenous ghrelin antagonist, but it is a multi-functional peptide hormone in its own right. In this review we will discuss the controversies associated with the discovery of obestatin and explore emerging central and peripheral roles of obestatin, which includes adipogenesis, pancreatic homeostasis and cancer.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Health
/
Disease
/
Ghrelin
Limits:
Animals
/
Humans
Language:
En
Journal:
Mol Cell Endocrinol
Year:
2011
Document type:
Article
Affiliation country:
Australia