Does 75 IU difference improve the cycle performance in poor responders? Comparison of daily 375 versus 450 IU gonadotrophin doses.
Gynecol Endocrinol
; 27(12): 1001-6, 2011 Dec.
Article
in En
| MEDLINE
| ID: mdl-21500998
ABSTRACT
OBJECTIVE:
To compare the efficacy on the cycle performance of 375 versus 450 IU/day gonadotrophin on the microdose flare-up protocol in poor responders. STUDYDESIGN:
A total of 91 poor responder patients who were treated with the microdose flare-up protocol were enrolled in this study. Group 1 (n = 40) was stimulated with 375 IU/day gonadotrophin. Group 2 (n = 51) was stimulated with 450 IU/day gonadotrophin. Main outcome measurements were accepted as the results of controlled ovarian hyperstimulation, implantation, clinical pregnancy, and live birth rates.RESULTS:
Baseline characteristics are similar between the two groups. Higher number of oocyte cumulus complexes and lower total gonadotrophin requirement were noted in Group 1 compared with Group 2. Number of metaphase II oocytes and implantation rates were similar between the groups. A trend toward higher clinical pregnancy and live birth rate was observed in Group 1 but these results did not reach statistical significance.CONCLUSIONS:
Total gonadotrophin costs are lower using the 375 IU/day gonadotrophin compared to the 450 IU/day in poor responders. Additional 75 IU/day does not give any improvement neither embryology nor pregnancy outcomes.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Ovulation Induction
/
Drug Resistance
/
Gonadotropins
/
Infertility
Type of study:
Diagnostic_studies
/
Guideline
/
Prognostic_studies
Limits:
Adult
/
Female
/
Humans
/
Male
/
Pregnancy
Language:
En
Journal:
Gynecol Endocrinol
Journal subject:
ENDOCRINOLOGIA
/
GINECOLOGIA
Year:
2011
Document type:
Article
Affiliation country:
Turquía