Molecular characterization of drug-resistant Mycobacterium tuberculosis isolates circulating in China by multilocus PCR and electrospray ionization mass spectrometry.

Wang, Feifei; Massire, Christian; Li, Haijing; Cummins, Lendell L; Li, Feng; Jin, Jialin; Fan, Xiaoping; Wang, Sen; Shao, Lingyun; Zhang, Shu; Meng, Shufang; Wu, Jing; Lu, Chanyi; Blyn, Lawrence B; Sampath, Rangarajan; Ecker, David J; Zhang, Wenhong; Tang, Yi-Wei

Wang, Feifei; Massire, Christian; Li, Haijing; Cummins, Lendell L; Li, Feng; Jin, Jialin; Fan, Xiaoping; Wang, Sen; Shao, Lingyun; Zhang, Shu; Meng, Shufang; Wu, Jing; Lu, Chanyi; Blyn, Lawrence B; Sampath, Rangarajan; Ecker, David J; Zhang, Wenhong; Tang, Yi-Wei.

Affiliation

Wang F; Department of Infectious Diseases, Huashan Hospital,and Institute of Biomedical Sciences, Fudan University, Shanghai, China.

J Clin Microbiol ; 49(7): 2719-21, 2011 Jul.

Article in En | MEDLINE | ID: mdl-21525214

ABSTRACT

We used multilocus PCR and electrospray ionization mass spectrometry (PCR/ESI-MS) to determine the genotype and drug resistance profiles for 96 Mycobacterium tuberculosis isolates circulating in regions of high and low tuberculosis (TB) endemicity in China. The dominant principal genetic group (PGG) circulating in China was PGG1, and drug-resistant gene mutations were more diversified in the region of low rather than high TB endemicity.

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Polymerase Chain Reaction / Tuberculosis, Multidrug-Resistant / Spectrometry, Mass, Electrospray Ionization / Molecular Typing / Mycobacterium tuberculosis Limits: Humans Country/Region as subject: Asia Language: En Journal: J Clin Microbiol Year: 2011 Document type: Article Affiliation country: China Country of publication: Estados Unidos

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