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Combination of farnesyltransferase and Akt inhibitors is synergistic in breast cancer cells and causes significant breast tumor regression in ErbB2 transgenic mice.
Balasis, Maria E; Forinash, Kara D; Chen, Y Ann; Fulp, William J; Coppola, Domenico; Hamilton, Andrew D; Cheng, Jin Q; Sebti, Saïd M.
Affiliation
  • Balasis ME; Drug Discovery Department, H Lee Moffitt Cancer Center and Research Institut, Yale University, New Haven, Connecticut, USA.
Clin Cancer Res ; 17(9): 2852-62, 2011 May 01.
Article in En | MEDLINE | ID: mdl-21536547
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Breast Neoplasms / Carcinoma / Antineoplastic Combined Chemotherapy Protocols / Enzyme Inhibitors / Farnesyltranstransferase / Oncogene Protein v-akt Type of study: Etiology_studies / Prognostic_studies Limits: Animals / Female / Humans Language: En Journal: Clin Cancer Res Journal subject: NEOPLASIAS Year: 2011 Document type: Article Affiliation country: Estados Unidos
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Breast Neoplasms / Carcinoma / Antineoplastic Combined Chemotherapy Protocols / Enzyme Inhibitors / Farnesyltranstransferase / Oncogene Protein v-akt Type of study: Etiology_studies / Prognostic_studies Limits: Animals / Female / Humans Language: En Journal: Clin Cancer Res Journal subject: NEOPLASIAS Year: 2011 Document type: Article Affiliation country: Estados Unidos