Anaphylaxis during the first course of high-dose methotrexate: a case report and literature review.
J Clin Pharm Ther
; 37(2): 245-8, 2012 Apr.
Article
in En
| MEDLINE
| ID: mdl-21569069
ABSTRACT
WHAT IS KNOWN AND OBJECTIVE:
Methotrexate (MTX) is widely used in the management of paediatric cancer with a generally favourable benefit/risk profile. We report an unusual adverse drug reaction with the first course of high-dose MTX in a paediatric patient and review the literature for similar cases. CASESUMMARY:
An 11-year-old boy with small-cell osteoblastic osteosarcoma in the lower limb experienced a case of life-threatening anaphylaxis during the first course of high-dose MTX. The adverse event occurred during the first course, likely due to an immune-mediated mechanism. We postulate that prior antineoplastic treatment might have contributed to the immune response to MTX. WHAT IS NEW ANDCONCLUSION:
Given that this reaction has rarely been reported, we discuss the present case with a review of other similar cases. Further studies are needed to substantiate this 'signal alarm' for serious MTX-related hypersensitivity reactions.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Methotrexate
/
Anaphylaxis
/
Antimetabolites, Antineoplastic
Type of study:
Etiology_studies
Limits:
Child
/
Humans
/
Male
Language:
En
Journal:
J Clin Pharm Ther
Journal subject:
FARMACIA
/
TERAPEUTICA
Year:
2012
Document type:
Article
Affiliation country:
Italia