[Fungal infections in cystic fibrosis]. / Infections fongiques au cours de la mucoviscidose.
Arch Pediatr
; 18 Suppl 1: S15-21, 2011 May.
Article
in Fr
| MEDLINE
| ID: mdl-21596282
ABSTRACT
Fungal colonization in cystic fibrosis patient is frequent and dominated by Aspergillus fumigatus (A. fumigatus). Mycological analysis on specific media showed other filamentous species Scedosporium, Geosmithia argillacea. Prospective studies are necessary to appreciate prevalence and pathogenicity in this pathology. A. fumigatus causes the most frequently allergic bronchopulmonary aspergillosis (ABPA). Invasive infection is exceptional in this context. An early diagnosis is important to avoid bronchial deterioration but is very difficult despite international consensus. New more specific biological markers are evaluated. Oral corticotherapy is the cornerstone of therapy but adverse effects are more frequent in cystic fibrosis. Antifungal therapy has a corticosteroid-sparing effect. New therapeutic strategies have to be evaluated.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Cystic Fibrosis
/
Mycoses
Type of study:
Diagnostic_studies
/
Etiology_studies
/
Observational_studies
/
Screening_studies
Limits:
Humans
Language:
Fr
Journal:
Arch Pediatr
Year:
2011
Document type:
Article
Affiliation country:
Francia