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Pharmacokinetics of oral tonapofylline and its acyl-glucuronide metabolite in patients with mild and moderate hepatic impairment.
Li, Zhaoyang; Gan, Liang-Shang; Marbury, Thomas; Lasseter, Kenneth C; Natarajan, Amy; Stecher, Scott; Wei, Dong; Yang, Liyu; Freedman, Daniel; Deykin, Aaron.
Affiliation
  • Li Z; Biogen Idec Inc, Cambridge, MA, USA. zhaoyang.li@genzyme.com
J Clin Pharmacol ; 52(4): 543-51, 2012 Apr.
Article in En | MEDLINE | ID: mdl-21610206
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Xanthines / Adenosine A1 Receptor Antagonists / Liver Diseases Type of study: Clinical_trials / Observational_studies / Prognostic_studies / Risk_factors_studies Limits: Aged / Female / Humans / Male / Middle aged Language: En Journal: J Clin Pharmacol Year: 2012 Document type: Article Affiliation country: Estados Unidos Country of publication: Reino Unido
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Xanthines / Adenosine A1 Receptor Antagonists / Liver Diseases Type of study: Clinical_trials / Observational_studies / Prognostic_studies / Risk_factors_studies Limits: Aged / Female / Humans / Male / Middle aged Language: En Journal: J Clin Pharmacol Year: 2012 Document type: Article Affiliation country: Estados Unidos Country of publication: Reino Unido