The selective phosphodiesterase 9 (PDE9) inhibitor PF-04447943 (6-[(3S,4S)-4-methyl-1-(pyrimidin-2-ylmethyl)pyrrolidin-3-yl]-1-(tetrahydro-2H-pyran-4-yl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one) enhances synaptic plasticity and cognitive function in rodents.

Hutson, P H; Finger, E N; Magliaro, B C; Smith, S M; Converso, A; Sanderson, P E; Mullins, D; Hyde, L A; Eschle, B K; Turnbull, Z; Sloan, H; Guzzi, M; Zhang, X; Wang, A; Rindgen, D; Mazzola, R; Vivian, J A; Eddins, D; Uslaner, J M; Bednar, R; Gambone, C; Le-Mair, W; Marino, M J; Sachs, N; Xu, G; Parmentier-Batteur, S

Hutson, P H; Finger, E N; Magliaro, B C; Smith, S M; Converso, A; Sanderson, P E; Mullins, D; Hyde, L A; Eschle, B K; Turnbull, Z; Sloan, H; Guzzi, M; Zhang, X; Wang, A; Rindgen, D; Mazzola, R; Vivian, J A; Eddins, D; Uslaner, J M; Bednar, R; Gambone, C; Le-Mair, W; Marino, M J; Sachs, N; Xu, G; Parmentier-Batteur, S.

Affiliation

Hutson PH; Merck & Co., Inc., Department of Neuroscience, West Point, PA 19486, USA. Peter_Hutson@merck.com

Neuropharmacology ; 61(4): 665-76, 2011 Sep.

Article in En | MEDLINE | ID: mdl-21619887

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Phosphodiesterase Inhibitors / Pyrazoles / Pyrimidinones / Synapses / Cognition / 3',5'-Cyclic-AMP Phosphodiesterases / Neuronal Plasticity Type of study: Prognostic_studies Limits: Animals / Female / Humans / Male Language: En Journal: Neuropharmacology Year: 2011 Document type: Article Affiliation country: Estados Unidos Country of publication: Reino Unido

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