Changes in the physiology of CA1 hippocampal pyramidal neurons in preplaque CRND8 mice.
Neurobiol Aging
; 33(8): 1609-23, 2012 Aug.
Article
in En
| MEDLINE
| ID: mdl-21676499
ABSTRACT
Amyloid-ß protein (Aß) is thought to play a central pathogenic role in Alzheimer's disease. Aß can impair synaptic transmission, but little is known about the effects of Aß on intrinsic cellular properties. Here we compared the cellular properties of CA1 hippocampal pyramidal neurons in acute slices from preplaque transgenic (Tg+) CRND8 mice and wild-type (Tg-) littermates. CA1 pyramidal neurons from Tg+ mice had narrower action potentials with faster decays than neurons from Tg- littermates. Action potential-evoked intracellular Ca(2+) transients in the apical dendrite were smaller in Tg+ than in Tg- neurons. Resting calcium concentration was higher in Tg+ than in Tg- neurons. The difference in action potential waveform was eliminated by low concentrations of tetraethylammonium ions and of 4-aminopyridine, implicating a fast delayed-rectifier potassium current. Consistent with this suggestion, there was a small increase in immunoreactivity for Kv3.1b in stratum radiatum in Tg+ mice. These changes in intrinsic properties may affect information flow through the hippocampus and contribute to the behavioral deficits observed in mouse models and patients with early-stage Alzheimer's disease.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Action Potentials
/
Amyloid beta-Peptides
/
Pyramidal Cells
/
Plaque, Amyloid
Limits:
Animals
Language:
En
Journal:
Neurobiol Aging
Year:
2012
Document type:
Article
Affiliation country:
Estados Unidos