Effect of gastric pH on the pharmacokinetics of a BCS class II compound in dogs: utilization of an artificial stomach and duodenum dissolution model and GastroPlus,&#8482; simulations to predict absorption.

Bhattachar, Shobha N; Perkins, Everett J; Tan, Jeffrey S; Burns, Lee J

Effect of gastric pH on the pharmacokinetics of a BCS class II compound in dogs: utilization of an artificial stomach and duodenum dissolution model and GastroPlus,™ simulations to predict absorption.

Bhattachar, Shobha N; Perkins, Everett J; Tan, Jeffrey S; Burns, Lee J.

Affiliation

Bhattachar SN; Pharmaceutical Sciences R&D, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, USA. Bhattachar_shobha_n@lilly.com

J Pharm Sci ; 100(11): 4756-65, 2011 Nov.

Article in En | MEDLINE | ID: mdl-21681753

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Artificial Organs / Pyrazoles / Quinolines / Duodenum / Gastric Juice / Gastric Mucosa / Hydrogen-Ion Concentration Type of study: Prognostic_studies / Risk_factors_studies Limits: Animals Language: En Journal: J Pharm Sci Year: 2011 Document type: Article Affiliation country: Estados Unidos

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