[Gene expression profiling in the first twelve weeks of treatment in chronic hepatitis C patients]. / Perfiles de expresión génica en las primeras doce semanas de tratamiento en pacientes con hepatitis C crónica.
Enferm Infecc Microbiol Clin
; 29(8): 573-80, 2011 Oct.
Article
in Es
| MEDLINE
| ID: mdl-21722999
ABSTRACT
INTRODUCTION:
Gene expression profiling in the first weeks of treatment of patients with chronic hepatitis C may contribute to better evaluate the response to interferon-based therapy. The objective of this study was to evaluate the gene expression profiles of early responders and non-responders before, and after 12 weeks of treatment with peginterferon alfa and ribavirin.METHODS:
Gene expression profiles were analysed in 12 patients with chronic hepatitis C, and scheduled for treatment with peginterferon alpha and ribavirin.RESULTS:
Of the 12 patients studied, six showed a complete early virological response, while six failed to control viremia. In early responders, treatment with peginterferon and ribavirin induced an increased expression of a larger number of interferon-induced genes (ISG15, IFI6, IFI44L, IFI27, MX1, OASL, IRF7, IFIT3, IFITM1, EIF2AK2, HERC5 and APOBEC3) than in non-responders (ISG15, IFI44L, IFI27, IRF7, USP18) in the first twelve weeks of treatment (P<0.05). In both groups, there were changes in the levels of certain genes poorly described in the treatment of hepatitis C so far.CONCLUSIONS:
The gene expression profiles described in this study provide a new insight to understanding the pathogenesis of the disease and treatment effect. The more marked effect of the treatment on the expression of interferon-response genes observed in early responders could explain their better control of viral load.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Antiviral Agents
/
Polyethylene Glycols
/
Ribavirin
/
Viremia
/
Interferon-alpha
/
Hepacivirus
/
Hepatitis C, Chronic
/
Gene Expression Profiling
Type of study:
Observational_studies
/
Risk_factors_studies
Limits:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Language:
Es
Journal:
Enferm Infecc Microbiol Clin
Journal subject:
DOENCAS TRANSMISSIVEIS
/
MICROBIOLOGIA
Year:
2011
Document type:
Article