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Neutralization of the γ-secretase activity by monoclonal antibody against extracellular domain of nicastrin.
Hayashi, I; Takatori, S; Urano, Y; Miyake, Y; Takagi, J; Sakata-Yanagimoto, M; Iwanari, H; Osawa, S; Morohashi, Y; Li, T; Wong, P C; Chiba, S; Kodama, T; Hamakubo, T; Tomita, T; Iwatsubo, T.
Affiliation
  • Hayashi I; Department of Neuropathology and Neuroscience, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan.
  • Takatori S; Department of Neuropathology and Neuroscience, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan.
  • Urano Y; Department of Systems Biology and Medicine, Research Center for Advanced Science and Technology, The University of Tokyo, Tokyo, Japan.
  • Miyake Y; Department of Clinical and Experimental Hematology, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Japan.
  • Takagi J; Laboratory of Protein Synthesis and Expression, Institute for Protein Research, Osaka University, Osaka, Japan.
  • Sakata-Yanagimoto M; Department of Clinical and Experimental Hematology, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Japan.
  • Iwanari H; Department of Systems Biology and Medicine, Research Center for Advanced Science and Technology, The University of Tokyo, Tokyo, Japan.
  • Osawa S; Perseus Proteomics Inc., Tokyo, Japan.
  • Morohashi Y; Department of Neuropathology and Neuroscience, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan.
  • Li T; Department of Neuropathology and Neuroscience, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan.
  • Wong PC; Department of Pathology, The Johns Hopkins University, School of Medicine, Baltimore, MD, USA.
  • Chiba S; Department of Pathology, The Johns Hopkins University, School of Medicine, Baltimore, MD, USA.
  • Kodama T; Department of Clinical and Experimental Hematology, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Japan.
  • Hamakubo T; Department of Systems Biology and Medicine, Research Center for Advanced Science and Technology, The University of Tokyo, Tokyo, Japan.
  • Tomita T; Department of Systems Biology and Medicine, Research Center for Advanced Science and Technology, The University of Tokyo, Tokyo, Japan.
  • Iwatsubo T; Department of Neuropathology and Neuroscience, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan.
Oncogene ; 31(6): 787-798, 2012 Feb 09.
Article in En | MEDLINE | ID: mdl-21725355
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Membrane Glycoproteins / Amyloid Precursor Protein Secretases / Antibodies, Neutralizing / Antibodies, Monoclonal Limits: Animals / Humans / Male Language: En Journal: Oncogene Journal subject: BIOLOGIA MOLECULAR / NEOPLASIAS Year: 2012 Document type: Article Affiliation country: Japón Country of publication: Reino Unido
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Membrane Glycoproteins / Amyloid Precursor Protein Secretases / Antibodies, Neutralizing / Antibodies, Monoclonal Limits: Animals / Humans / Male Language: En Journal: Oncogene Journal subject: BIOLOGIA MOLECULAR / NEOPLASIAS Year: 2012 Document type: Article Affiliation country: Japón Country of publication: Reino Unido