Adjuvants, Immunologic/chemical synthesis; Chemistry, Pharmaceutical/methods; Immunologic Factors/chemical synthesis; Oligoribonucleotides/chemical synthesis; Phosphorothioate Oligonucleotides/chemical synthesis; Toll-Like Receptor 7/agonists; Toll-Like Receptor 8/agonists; Adjuvants, Immunologic/isolation & purification; Adjuvants, Immunologic/pharmacology; Chromatography, High Pressure Liquid; Communicable Diseases/drug therapy; Communicable Diseases/immunology; Communicable Diseases/pathology; Drug Stability; Electrophoresis, Capillary; Humans; Hypersensitivity/drug therapy; Hypersensitivity/immunology; Hypersensitivity/pathology; Immunologic Factors/isolation & purification; Immunologic Factors/pharmacology; Neoplasms/drug therapy; Neoplasms/immunology; Neoplasms/pathology; Oligoribonucleotides/isolation & purification; Oligoribonucleotides/pharmacology; Phosphorothioate Oligonucleotides/isolation & purification; Phosphorothioate Oligonucleotides/pharmacology; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Toll-Like Receptor 7/immunology; Toll-Like Receptor 7/metabolism; Toll-Like Receptor 8/immunology; Toll-Like Receptor 8/metabolism