Effect of carotenoid supplementation on plasma carotenoids, inflammation and visual development in preterm infants.
J Perinatol
; 32(6): 418-24, 2012 Jun.
Article
in En
| MEDLINE
| ID: mdl-21760585
ABSTRACT
OBJECTIVE:
Dietary carotenoids (lutein, lycopene and ß-carotene) may be important in preventing or ameliorating prematurity complications. Little is known about carotenoid status or effects of supplementation. STUDYDESIGN:
This randomized controlled multicenter trial compared plasma carotenoid levels among preterm infants (n=203, <33 weeks gestational age) fed diets with and without added lutein, lycopene and ß-carotene with human milk (HM)-fed term infants. We assessed safety and health.RESULT:
Plasma carotenoid levels were higher in the supplemented group at all time points (P<0.0001) and were similar to those of term HM-fed infants. Supplemented infants had lower plasma C-reactive protein (P<0.001). Plasma lutein levels correlated with the full field electroretinogram-saturated response amplitude in rod photoreceptors (r=0.361, P=0.05). The supplemented group also showed greater rod photoreceptor sensitivity (least squares means 6.1 vs 4.1; P<0.05).CONCLUSION:
Carotenoid supplementation for preterm infants raises plasma concentrations to those observed in HM-fed term infants. Carotenoid supplementation may decrease inflammation. Our results point to protective effects of lutein on preterm retina health and maturation.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Retina
/
Vision, Ocular
/
Carotenoids
/
Dietary Supplements
/
Infant, Premature, Diseases
/
Inflammation
Type of study:
Clinical_trials
Limits:
Female
/
Humans
/
Male
/
Newborn
Language:
En
Journal:
J Perinatol
Journal subject:
PERINATOLOGIA
Year:
2012
Document type:
Article
Affiliation country:
Estados Unidos