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Synthesis and structure-activity relations in the class of 2-(pyridyl)penems.
Bedeschi, A; Visentin, G; Perrone, E; Giudici, F; Zarini, F; Franceschi, G; Meinardi, G; Castellani, P; Jabes, D; Rossi, R.
Affiliation
  • Bedeschi A; Farmitalia Carlo Erba SpA, R. & D., Infectious Diseases Dept., Milan, Italy.
J Antibiot (Tokyo) ; 43(3): 306-13, 1990 Mar.
Article in En | MEDLINE | ID: mdl-2182592
ABSTRACT
The isosteric CH----N substitution in the class of 2-arylpenems results in improved antibacterial activity, with retention of the favorable characteristic of stability towards renal dehydropeptidase. High therapeutic efficacy was demonstrated in experimental mice septicemias with the 2-(3-pyridyl) derivative 2b and its orally absorbed acetoxymethyl ester prodrug 4n.
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Collection: 01-internacional Database: MEDLINE Main subject: Pyridines / Bacteria / Beta-Lactamases / Sepsis / Anti-Bacterial Agents Type of study: Prognostic_studies Limits: Animals Language: En Journal: J Antibiot (Tokyo) Year: 1990 Document type: Article Affiliation country: Italia
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Collection: 01-internacional Database: MEDLINE Main subject: Pyridines / Bacteria / Beta-Lactamases / Sepsis / Anti-Bacterial Agents Type of study: Prognostic_studies Limits: Animals Language: En Journal: J Antibiot (Tokyo) Year: 1990 Document type: Article Affiliation country: Italia