Computational analysis of two species C human adenoviruses provides evidence of a novel virus.
J Clin Microbiol
; 49(10): 3482-90, 2011 Oct.
Article
in En
| MEDLINE
| ID: mdl-21849694
ABSTRACT
Human adenovirus C (HAdV-C) species are a common cause of respiratory infections and can occasionally produce severe clinical manifestations. A deeper understanding of the variation and evolution in species HAdV-C is especially important since these viruses, including HAdV-C6, are used as gene delivery vectors for human gene therapy and in other biotechnological applications. Here, the full-genome analysis of the prototype HAdV-C6 and a recently identified virus provisionally termed HAdV-C57 are reported. Although the genomes of all species HAdV-C members are very similar to each other, the E3 region, hexon and fiber (ten proteins total) present a wide range of identity values at the amino acid level. Studies of these viruses in comparison to the other three HAdV-C prototypes (1, 2, and 5) comprise a comprehensive analysis of the diversity and conservation within HAdV-C species. HAdV-C6 contains a recombination event within the constant region of the hexon gene. HAdV-C57 is a recombinant virus with a fiber gene nearly identical to HAdV-C6 and a unique hexon distinguished by its loop 2 motif.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Phylogeny
/
DNA, Viral
/
Adenoviruses, Human
/
Genome, Viral
Limits:
Humans
Language:
En
Journal:
J Clin Microbiol
Year:
2011
Document type:
Article
Affiliation country:
Estados Unidos