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The proinflammatory cytokine GM-CSF downregulates fetal hemoglobin expression by attenuating the cAMP-dependent pathway in sickle cell disease.
Ikuta, Tohru; Adekile, Adekunle D; Gutsaeva, Diana R; Parkerson, James B; Yerigenahally, Shobha D; Clair, Betsy; Kutlar, Abdullah; Odo, Nadine; Head, C Alvin.
Affiliation
  • Ikuta T; Department of Anesthesiology and Perioperative Medicine, Medical College of Georgia, Georgia Health Sciences University, Augusta, USA. tikuta@georgiahealth.edu
Blood Cells Mol Dis ; 47(4): 235-42, 2011 Dec 15.
Article in En | MEDLINE | ID: mdl-21945571
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Fetal Hemoglobin / Signal Transduction / Down-Regulation / Granulocyte-Macrophage Colony-Stimulating Factor / Cyclic AMP / Anemia, Sickle Cell Type of study: Observational_studies / Prognostic_studies / Risk_factors_studies Limits: Humans Language: En Journal: Blood Cells Mol Dis Journal subject: HEMATOLOGIA Year: 2011 Document type: Article Affiliation country: Estados Unidos Country of publication: Estados Unidos
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Fetal Hemoglobin / Signal Transduction / Down-Regulation / Granulocyte-Macrophage Colony-Stimulating Factor / Cyclic AMP / Anemia, Sickle Cell Type of study: Observational_studies / Prognostic_studies / Risk_factors_studies Limits: Humans Language: En Journal: Blood Cells Mol Dis Journal subject: HEMATOLOGIA Year: 2011 Document type: Article Affiliation country: Estados Unidos Country of publication: Estados Unidos