[An unusual lesion of the nasopharynx: oncocytic metaplasia]. / Une lésion inhabituelle du nasopharynx : la métaplasie oncocytaire.
Ann Pathol
; 31(5): 396-8, 2011 Oct.
Article
in Fr
| MEDLINE
| ID: mdl-21982249
ABSTRACT
Oncocytic metaplasia of the nasopharynx is an exceptional lesion which exact etiopathogenesis, although largely discussed, still remains controversial. The purpose of this paper is to present the epidemiological characteristics and clinical signs of this lesion and to study its pathogenesis and its therapeutic modalities. We report two cases that occurred respectively in a 53- and 60-year-old woman. The first presented with pharyngeal dysesthesia and otalgia. The endoscopic examination revealed an irregularity of the posterior wall of the nasopharynx. The second patient presented with tinnitus, discomfort of the left ear and bilateral hearing loss. Endoscopic exam revealed a bilateral structural abnormality to the eardrum. Microscopy showed focal oncocytic metaplasia of the nasopharynx mucosa in both cases. There was a positive outcare for both patients after excisional biopsy. Oncocytic metaplasia seems to be in relation to the stimulation of sympathic neuropeptidergic nerve fibers which target epithelial, connective, endothelial and lymphoid cells.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Nasopharynx
/
Oxyphil Cells
Type of study:
Etiology_studies
Limits:
Female
/
Humans
/
Middle aged
Language:
Fr
Journal:
Ann Pathol
Year:
2011
Document type:
Article
Affiliation country:
Túnez