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Characterisation and sequence of a protective rhoptry antigen from Plasmodium falciparum.
Ridley, R G; Takacs, B; Lahm, H W; Delves, C J; Goman, M; Certa, U; Matile, H; Woollett, G R; Scaife, J G.
Affiliation
  • Ridley RG; Department of Molecular Biology, University of Edinburgh, U.K.
Mol Biochem Parasitol ; 41(1): 125-34, 1990 Jun.
Article in En | MEDLINE | ID: mdl-2200961
We have recently demonstrated that a non-polymorphic rhoptry antigen, RAP-1 (rhoptry associated protein-1), which is recognised by human immune serum, can successfully protect Saimiri monkeys from a lethal infection of Plasmodium falciparum malaria. In this report we further characterise the antigen, which consists of four major proteins of 80, 65, 42 and 40 kDa and two minor proteins of 77 and 70 kDa, and present the antigen's gene sequence. Monoclonal antibody evidence, autocatalytic processing and immunological cross-reactivity suggest that all components of this antigen are derived from the same precursor protein. The antigen is lipophilic, and disulphide bonding plays an important role in its structure. We discuss the structure and function of RAP-1 in the light of its deduced amino acid sequence and consider the relationship of this antigen to other rhoptry antigens of similar subunit size and composition.
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Collection: 01-internacional Database: MEDLINE Main subject: Plasmodium falciparum / Protozoan Proteins / Antigens, Protozoan Type of study: Risk_factors_studies / Systematic_reviews Limits: Animals Language: En Journal: Mol Biochem Parasitol Year: 1990 Document type: Article Country of publication: Países Bajos
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Collection: 01-internacional Database: MEDLINE Main subject: Plasmodium falciparum / Protozoan Proteins / Antigens, Protozoan Type of study: Risk_factors_studies / Systematic_reviews Limits: Animals Language: En Journal: Mol Biochem Parasitol Year: 1990 Document type: Article Country of publication: Países Bajos