HTLV-2 APH-2 expression is correlated with proviral load but APH-2 does not promote lymphocytosis.
J Infect Dis
; 205(1): 82-6, 2012 Jan 01.
Article
in En
| MEDLINE
| ID: mdl-22065675
ABSTRACT
We recently discovered the antisense protein of human T-cell leukemia virus (HTLV) type 2 (APH-2), whose messenger RNA is encoded by the antisense strand of the HTLV-2 genome. We quantified proviral load, level of tax, and APH-2 in a series of blood samples obtained from a cohort of HTLV-2 carriers. We determined whether APH-2 promotes cell proliferation. APH-2 was detectable in most samples tested and was correlated with proviral load. APH-2 levels were not correlated with lymphocyte count in vivo, consistent with the inability of APH-2 to promote cell proliferation in vitro. APH-2 does not promote cell proliferation and does not cause lymphocytosis.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Human T-lymphotropic virus 2
/
HTLV-II Infections
/
Retroviridae Proteins
/
Proviruses
/
Viral Load
/
Lymphocytosis
Type of study:
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limits:
Adult
/
Aged
/
Aged80
/
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
J Infect Dis
Year:
2012
Document type:
Article
Affiliation country:
Francia