Soymorphin-5, a soy-derived µ-opioid peptide, decreases glucose and triglyceride levels through activating adiponectin and PPARα systems in diabetic KKAy mice.
Am J Physiol Endocrinol Metab
; 302(4): E433-40, 2012 Feb 15.
Article
in En
| MEDLINE
| ID: mdl-22127231
ABSTRACT
Soymorphin-5 (YPFVV) derived from soybean ß-conglycinin ß-subunit is a µ-opioid agonist peptide having anxiolytic-like activity. Here, we show that soymorphin-5 improves glucose and lipid metabolism after long-term oral administration to KKAy mice, a type 2 diabetes model animal. Soymorphin-5 inhibited hyperglycemia without an increase in plasma insulin levels in KKAy mice. Soymorphin-5 also decreased plasma and liver triglyceride (TG) levels and liver weight, suggesting that soymorphin-5 improved lipid metabolism. Soymorphin-5 increased plasma adiponectin concentration and liver mRNA expression of AdipoR2, a subtype of adiponectin receptor that is involved in stimulating the peroxisome proliferator-activated receptor (PPAR)α pathway and fatty acid ß-oxidation. The expressions of the mRNA of PPARα and its target genes acyl-CoA oxidase, carnitine palmitoyltransferase 1 A, and uncoupling protein-2, in the liver were also increased after oral administration of soymorphin-5. Furthermore, des-Tyr-soymorphin-5 (PFVV) without µ-opioid and anxiolytic-like activities did not decrease blood glucose levels in KKAy mice. These results suggest that µ-opioid peptide soymorphin-5 improves glucose and lipid metabolism via activation of the adiponectin and PPARα system and subsequent increases of ß-oxidation and energy expenditure in KKAy mice.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Peptide Fragments
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Triglycerides
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Blood Glucose
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Opioid Peptides
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Soybean Proteins
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PPAR alpha
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Adiponectin
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Hyperglycemia
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Hypoglycemic Agents
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Hypolipidemic Agents
Limits:
Animals
Language:
En
Journal:
Am J Physiol Endocrinol Metab
Journal subject:
ENDOCRINOLOGIA
/
FISIOLOGIA
/
METABOLISMO
Year:
2012
Document type:
Article
Affiliation country:
Japón