[Pemetrexed salvage chemotherapy for NSCLC: implementation study]. / Traitement de rattrapage par pémétrexed pour les CBNPC: étude rétrospective d'implémentation.
Rev Mal Respir
; 29(1): 21-7, 2012 Jan.
Article
in Fr
| MEDLINE
| ID: mdl-22240216
ABSTRACT
BACKGROUND:
Registration trials demonstrated the activity of pemetrexed in non small cell lung carcinoma (NSCLC) either in combination with first-line agents or in monotherapy for salvage treatment. The aim of our implementation study was to verify, in an unselected population, the results obtained with pemetrexed salvage chemotherapy in clinical practice. PATIENTS ANDMETHODS:
The charts of all patients diagnosed with NSCLC, receiving pemetrexed for progressive disease after at least one previous course of chemotherapy, were retrospectively reviewed in two academic institutions. Response was assessed according to WHO and toxicity using the CTCAE and WHO criteria.RESULTS:
Between November 2004 and September 2009, 84 patients were given pemetrexed as second, third or greater than third line therapy (n=18/14/52). Intent-to-treat response rate was 11.9% (95% CI, 5%-18.8%). Median progression-free survival was 2.2 months and median survival time was 6.4 months. The most frequent grade 3-5 toxicity was neutropenia (23.9%).CONCLUSION:
Salvage chemotherapy with pemetrexed for progressing NSCLC confirmed, in an unselected population, who had been extensively treated previously, the level of activity observed in registration trials although a significant toxicity was noted.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Carcinoma, Non-Small-Cell Lung
/
Glutamates
/
Guanine
/
Lung Neoplasms
Type of study:
Evaluation_studies
/
Observational_studies
/
Sysrev_observational_studies
Aspects:
Implementation_research
Limits:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Language:
Fr
Journal:
Rev Mal Respir
Year:
2012
Document type:
Article
Affiliation country:
Bélgica