[Absorption dynamic characteristics of clopidogrel bisulfate polymorphs in rat].
Yao Xue Xue Bao
; 46(10): 1268-72, 2011 Oct.
Article
in Zh
| MEDLINE
| ID: mdl-22242463
ABSTRACT
Four crystalline forms of clopidogrel bisulfate were characterized by analytical techniques. Aiming to research the absorption characteristics of clopidogrel bisulfate polymorphs after taken orally by rat, and to estimate the influence of crystal form to pharmacodynamic action, four crystalline forms of clopidogrel bisulfate were administered intragastrically to rats, and high performance liquid chromatography (HPLC) was used to measure the contents of clopidogrel bisulfate and its metabolite in rat plasma. The metabolite of clopidogrel bisulfate was detected in rat plasma. There were significant deviations among four crystalline forms in the areas under curve of the metabolite of clopidogrel bisulfate. We concluded that the different crystal forms of clopidogrel bisulfate showed different pharmacokinetic characteristics, which might affect pharmacodynamic action.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Ticlopidine
/
Platelet Aggregation Inhibitors
Type of study:
Prognostic_studies
Limits:
Animals
Language:
Zh
Journal:
Yao Xue Xue Bao
Year:
2011
Document type:
Article
Affiliation country:
China