Risk of preterm delivery in non-diabetic women with polycystic ovarian syndrome.
J Perinatol
; 32(10): 770-6, 2012 Oct.
Article
in En
| MEDLINE
| ID: mdl-22261835
ABSTRACT
OBJECTIVE:
To examine the risk and etiology of preterm delivery in women with polycystic ovary syndrome (PCOS). STUDYDESIGN:
Retrospective cohort study comparing preterm delivery rate among non-diabetic PCOS and non-PCOS women with singleton pregnancy. Multivariable logistic regression was used to identify predictors of preterm delivery among PCOS women.RESULT:
Among 908 PCOS women with singleton pregnancy, 12.9% delivered preterm compared with 7.4% among non-PCOS women (P<0.01). Causes of preterm delivery among PCOS women included preterm labor (41%), cervical insufficiency (11%), hypertensive complications (20%), preterm premature rupture of membranes (15%), fetal-placental concerns (9%) and intrauterine fetal demise (5%). Maternal age, race/ethnicity and nulliparity were significant predictors of preterm delivery in PCOS, whereas body mass index and fertility medications were not.CONCLUSION:
A higher proportion of PCOS women delivered preterm (12.9%) compared with non-PCOS women, with the majority of cases due to spontaneous preterm birth. Future studies should explore etiologies and strategies to improve pregnancy outcomes in PCOS.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Polycystic Ovary Syndrome
/
Premature Birth
Type of study:
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limits:
Adult
/
Female
/
Humans
/
Pregnancy
Language:
En
Journal:
J Perinatol
Journal subject:
PERINATOLOGIA
Year:
2012
Document type:
Article
Affiliation country:
Estados Unidos