[Keratin fragments as a serological indicator in patients with a liver disease]. / Keratinové fragmenty jako sérologický ukazatel u nemocných s jaterní chorobou.
Vnitr Lek
; 57(12): 1025-8, 2011 Dec.
Article
in Cs
| MEDLINE
| ID: mdl-22277036
ABSTRACT
INTRODUCTION:
Determination of M30 antigen appears to be a sensitive method for evaluation of hepatocyte apoptosis. The aim of the present project was to implement this technique, compare M30 values in patients with a liver disease and healthy controls and to identify potential relationships between M30 values and other parameters.METHODS:
M30 antigen was assessed in 25 patients with a liver disease and 30 healthy controls. These results were compared between patients with a liver disease and the controls and correlated to a range of clinical and laboratory values, including tissue polypeptide-specific antigen (TPS), in patients with a liver disease.RESULTS:
We found significant differences in M30 values between controls and patients with a liver disease. The only significant correlations were the correlation between M30 and ALT, highly significant correlation between M30 and AST and highly significant correlation between M30 and TPS.CONCLUSION:
The M30 antigen is a sensitive indicator of liver damage. Considering the highly significant correlation with TPS, it can be assumed that in some liver diseases, TPS could serve as a clinically useful indicator of apoptosis.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Peptide Fragments
/
Peptides
/
Keratin-18
/
Liver Diseases
Type of study:
Prognostic_studies
Limits:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Language:
Cs
Journal:
Vnitr Lek
Year:
2011
Document type:
Article