Synthesis of substituted 1H-indazoles from arynes and hydrazones.
J Org Chem
; 77(7): 3149-58, 2012 Apr 06.
Article
in En
| MEDLINE
| ID: mdl-22414117
ABSTRACT
The 1H-indazole skeleton can be constructed by a [3 + 2] annulation approach from arynes and hydrazones. Under different reaction conditions, both N-tosylhydrazones and N-aryl/alkylhydrazones can be used to afford a variety of indazoles. The former reaction affords 3-substituted indazoles either via in situ generated diazo compounds or through an annulation/elimination process. The latter reaction leads to 1,3-disubstituted indazoles likely through an annulation/oxidation process. The reactions operate under mild conditions and can accommodate aryl, vinyl, and less satisfactorily, alkyl groups.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Hydrazones
/
Indazoles
Language:
En
Journal:
J Org Chem
Year:
2012
Document type:
Article