Fetal programming of stress responses.
Stress
; 4(4): 263-71, 2001 Dec.
Article
in En
| MEDLINE
| ID: mdl-22432146
Epidemiological studies have shown that small size at birth is associated with an increased risk of coronary heart disease and its risk factors, including hypertension and Type 2 diabetes.It is suggested that these observations linking low birthweight with disease result from an imbalance between fetal nutrient demand and supply. This imbalance results in metabolic and endocrine adaptations, which benefit the fetus in the short term by reducing fetal growth and increasing fuel availability, but in the longer term they are maladaptive leading to an increased risk of coronary heart disease. Experimental data in animals and recent human observations have suggested that alterations in the set point of the hypothalamic-pituitary-adrenal axis and sympathoadrenal system are important long-term changes that occur in association with reduced fetal growth. These data suggest that the nature and amplitude of the stress response may be determined by intrauterine factors.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Pituitary-Adrenal System
/
Stress, Physiological
/
Sympathetic Nervous System
/
Fetal Development
/
Fetal Growth Retardation
/
Hypothalamo-Hypophyseal System
Type of study:
Risk_factors_studies
Limits:
Animals
/
Female
/
Humans
/
Pregnancy
Language:
En
Journal:
Stress
Journal subject:
NEUROLOGIA
Year:
2001
Document type:
Article
Country of publication:
Reino Unido