The quinoline imidoselenocarbamate EI201 blocks the AKT/mTOR pathway and targets cancer stem cells leading to a strong antitumor activity.

Ibáñez, E; Agliano, A; Prior, C; Nguewa, P; Redrado, M; González-Zubeldia, I; Plano, D; Palop, J A; Sanmartín, C; Calvo, A

Ibáñez, E; Agliano, A; Prior, C; Nguewa, P; Redrado, M; González-Zubeldia, I; Plano, D; Palop, J A; Sanmartín, C; Calvo, A.

Affiliation

Ibáñez E; Synthesis Section, Department of Organic and Pharmaceutical Chemistry, University of Navarra, Irunlarrea, 1, E-31008 Pamplona, Spain.

Curr Med Chem ; 19(18): 3031-43, 2012.

Article in En | MEDLINE | ID: mdl-22455594

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Collection: 01-internacional Database: MEDLINE Main subject: Organoselenium Compounds / Protein Kinase Inhibitors / Proto-Oncogene Proteins c-akt / TOR Serine-Threonine Kinases / Neoplasms / Antineoplastic Agents Limits: Animals / Humans / Male Language: En Journal: Curr Med Chem Journal subject: QUIMICA Year: 2012 Document type: Article Affiliation country: España Country of publication: Emiratos Árabes Unidos

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