Replacement oral ethinyloestradiol therapy for gonadal dysgenesis: growth and adrenal androgen studies.
Acta Endocrinol (Copenh)
; 91(3): 519-28, 1979 Jul.
Article
in En
| MEDLINE
| ID: mdl-224633
ABSTRACT
We have studied growth and adrenal dehydroepiandrosterone (DHA) responses to iv synthetic adrenocorticotrophic hormone (ACTH, Cortrosyn) in 6 girls with gonadal dysgenesis before and during treatment with low-dose ethinyloestradiol (EOe2). In all patients there was a statisfactory induction of secondary sexual characteristics including increase in breasts and public hair and onset of withdrawal bleeding within 6 months of therapy. Height velocity increased from 2.8 +/- 0.9 cm/year pre-treatment to 5.3 +/- 1.5 cm/year (P less than 0.02) in the first year. There was deceleration to 1.9 +/- 1.1 cm/year in the second year. There was no disproportionate advancement in bone age and thus, presumably, no loss of ultimate height. We could demonstrate no change in basal or ACTH-stimulated levels of DHA, a specific adrenal androgen, to account for the increased public hair and growth in these patients.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Turner Syndrome
/
Dehydroepiandrosterone
/
Adrenocorticotropic Hormone
/
Ethinyl Estradiol
Limits:
Adolescent
/
Female
/
Humans
Language:
En
Journal:
Acta Endocrinol (Copenh)
Year:
1979
Document type:
Article