Diet-induced models of obesity (DIO) in rodents.
Curr Protoc Neurosci
; Chapter 9: Unit 9.38.1-13, 2012 Apr.
Article
in En
| MEDLINE
| ID: mdl-22470151
ABSTRACT
Obesity results from a complex interplay between a susceptible genotype and an environment that both promotes increased caloric intake and enables sustained decreases in energy expenditure. One commonly employed approach to modeling obesity in preclinical species is the diet-induced obese (DIO) rodent. Here, theoretical and practical considerations for producing obese rodents via dietary manipulation, and for assessing drug-induced changes in food intake and body weight are described. Based on these considerations, a standardized protocol for diet-induced obesity in both mouse and rat is provided and sample data from these models are also described.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Food, Formulated
/
Disease Models, Animal
/
Obesity
Type of study:
Guideline
Limits:
Animals
Language:
En
Journal:
Curr Protoc Neurosci
Year:
2012
Document type:
Article
Affiliation country:
Estados Unidos