Genetic variation in PLAG1 associates with early life body weight and peripubertal weight and growth in Bos taurus.
Anim Genet
; 43(5): 591-4, 2012 Oct.
Article
in En
| MEDLINE
| ID: mdl-22497486
ABSTRACT
Variation at the pleiomorphic adenoma gene 1 (PLAG1) locus has recently been implicated in the regulation of stature and weight in Bos taurus. Using a population of 942 outbred Holstein-Friesian dairy calves, we report confirmation of this effect, demonstrating strong association of early life body weight with PLAG1 genotype. Peripubertal body weight and growth rate were also significantly associated with PLAG1 genotype. Growth rate per kilogram of body weight, daily feed intake, gross feed efficiency and residual feed intake were not significantly associated with PLAG1 genotype. This study supports the status of PLAG1 as a key regulator of mammalian growth. Further, the data indicate the utility of PLAG1 polymorphisms for the selection of animals to achieve enhanced weight gain or conversely to aid the selection of animals with lower mature body weight and thus lower maintenance energy requirements.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Polymorphism, Genetic
/
Cattle
/
DNA-Binding Proteins
Type of study:
Risk_factors_studies
Aspects:
Patient_preference
Limits:
Animals
Language:
En
Journal:
Anim Genet
Journal subject:
GENETICA
/
MEDICINA VETERINARIA
Year:
2012
Document type:
Article
Affiliation country:
Nueva Zelanda