Effects of hypoxia-inducible factor 1α on bone conduction impairment in otitis media with effusion.
Acta Otolaryngol
; 132(9): 938-43, 2012 Sep.
Article
in En
| MEDLINE
| ID: mdl-22568633
ABSTRACT
CONCLUSION:
Elevated levels of hypoxia-inducible factor 1α (HIF-1α) in middle ear effusion may play an important role in the pathogenesis of bone conduction impairment associated with otitis media with effusion (OME). The mechanism may be related to the up-regulation of nitric oxide (NO) expression.OBJECTIVES:
This study was undertaken to investigate the role of HIF-1α in the pathogenesis of sensorineural hearing loss associated with OME.METHODS:
One hundred and eight OME patients were divided into two groups OME without bone conduction impairment (group 1) and OME with bone conduction impairment (group 2). The levels of HIF-1α, NO, and quinolinic acid (QUIN) in the middle ear effusion and serum of these patients were investigated. The relationship between these factors and the bone conduction threshold (BCT) differences were analyzed.RESULTS:
The levels of HIF-1α and NO concentrations in the middle ear effusion were found to be signiï¬cantly higher in group 2 than in group 1 (both p < 0.05). The OME patients' BCT differences at 4000 Hz were correlated with the levels of HIF-1α and the NO concentrations in the middle ear effusion. Furthermore, the HIF-1α levels were correlated with the levels of NO but not with the levels of QUIN in the effusion.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Bone Conduction
/
Otitis Media with Effusion
/
Hypoxia-Inducible Factor 1, alpha Subunit
/
Hearing Loss, Conductive
Limits:
Adolescent
/
Adult
/
Child
/
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
Acta Otolaryngol
Year:
2012
Document type:
Article
Affiliation country:
China