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Association of polymorphism +874 A/T of interferon-γ and susceptibility to the development of tuberculosis: meta-analysis.
de Albuquerque, A C; Rocha, L Q; de Morais Batista, A H; Teixeira, A B; Dos Santos, D B; Nogueira, N A P.
Affiliation
  • de Albuquerque AC; Research Laboratory of Applied Microbiology, Federal University of Ceará, Ceará, Fortaleza, Brazil. adriana.carvalhodealbuquerque@gmail.com
Eur J Clin Microbiol Infect Dis ; 31(11): 2887-95, 2012 Nov.
Article in En | MEDLINE | ID: mdl-22684265
ABSTRACT
The immune defence against Mycobacterium tuberculosis is complex and involves multiple interacting cells. Studies in subjects with polymorphisms in genes for IFN or its receptor gene evaluate their relationship with mycobacterium infections. The purpose of this study was to analyze the evidence of the effect of polymorphism +874 A/T from interferon-γ on the occurrence of tuberculosis. We performed a meta-analysis of studies published between June 2002 and April 2012. The articles analyzed assessed the relationship between the polymorphism +874 A/T and the development of tuberculosis. The meta-analysis was performed with a random effect model, considering the heterogeneity among studies. Genotype TT showed a protective effect (OR, 0.77; 95% CI = 0.67-0.88) while genotype AA may be associated with increased susceptibility to developing tuberculosis (OR, 1.51; 95% CI = 1.38-1.65). In relation to alleles, we can verify that the A allele is related to the development of tuberculosis (OR, 1.56; 95% CI = 1.42-1.71). This information reinforces the importance of host genetics in the development of infectious diseases. Studies in this area can result in the promotion of new and more accurate genetic markers.
Subject(s)

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Tuberculosis / Interferon-gamma / Genetic Predisposition to Disease / Polymorphism, Single Nucleotide / Mycobacterium tuberculosis Type of study: Risk_factors_studies / Systematic_reviews Limits: Humans Language: En Journal: Eur J Clin Microbiol Infect Dis Journal subject: DOENCAS TRANSMISSIVEIS / MICROBIOLOGIA Year: 2012 Document type: Article Affiliation country: Brasil

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Tuberculosis / Interferon-gamma / Genetic Predisposition to Disease / Polymorphism, Single Nucleotide / Mycobacterium tuberculosis Type of study: Risk_factors_studies / Systematic_reviews Limits: Humans Language: En Journal: Eur J Clin Microbiol Infect Dis Journal subject: DOENCAS TRANSMISSIVEIS / MICROBIOLOGIA Year: 2012 Document type: Article Affiliation country: Brasil