Identification of a potent sodium hydrogen exchanger isoform 1 (NHE1) inhibitor with a suitable profile for chronic dosing and demonstrated cardioprotective effects in a preclinical model of myocardial infarction in the rat.

Huber, John D; Bentzien, Jörg; Boyer, Stephen J; Burke, Jennifer; De Lombaert, Stéphane; Eickmeier, Christian; Guo, Xin; Haist, James V; Hickey, Eugene R; Kaplita, Paul; Karmazyn, Morris; Kemper, Raymond; Kennedy, Charles A; Kirrane, Thomas; Madwed, Jeffrey B; Mainolfi, Elizabeth; Nagaraja, Nelamangara; Soleymanzadeh, Fariba; Swinamer, Alan; Eldrup, Anne B

Huber, John D; Bentzien, Jörg; Boyer, Stephen J; Burke, Jennifer; De Lombaert, Stéphane; Eickmeier, Christian; Guo, Xin; Haist, James V; Hickey, Eugene R; Kaplita, Paul; Karmazyn, Morris; Kemper, Raymond; Kennedy, Charles A; Kirrane, Thomas; Madwed, Jeffrey B; Mainolfi, Elizabeth; Nagaraja, Nelamangara; Soleymanzadeh, Fariba; Swinamer, Alan; Eldrup, Anne B.

Affiliation

Huber JD; Department of Medicinal Chemistry, Boehringer Ingelheim Pharmaceuticals, Ridgefield, Connecticut 06877, United States. john.huber@boehringeringelheim.com

J Med Chem ; 55(16): 7114-40, 2012 Aug 23.

Article in En | MEDLINE | ID: mdl-22803959

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Benzamides / Myocardial Reperfusion Injury / Sodium-Hydrogen Exchangers / Guanidines / Myocardial Infarction Type of study: Diagnostic_studies Limits: Animals / Humans / Male Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2012 Document type: Article Affiliation country: Estados Unidos Country of publication: Estados Unidos

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