The non-classical ArsR-family repressor PyeR (PA4354) modulates biofilm formation in Pseudomonas aeruginosa.
Microbiology (Reading)
; 158(Pt 10): 2598-2609, 2012 Oct.
Article
in En
| MEDLINE
| ID: mdl-22820840
ABSTRACT
PyeR (PA4354) is a novel member of the ArsR family of transcriptional regulators and modulates biofilm formation in Pseudomonas aeruginosa. Characterization of this regulator showed that it has negative autoregulatory properties and binds to a palindromic motif conserved among PyeR orthologues. These characteristics are in line with classical ArsR-family regulators, as is the fact that PyeR is part of an operon structure (pyeR-pyeM-xenB). However, PyeR also exhibits some atypical features in comparison with classical members of the ArsR family, as it does not harbour metal-binding motifs and does not appear to be involved in metal perception or resistance. Hence, PyeR belongs to a subgroup of non-classical ArsR-family regulators and is the second ArsR regulator shown to be involved in biofilm formation.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Pseudomonas aeruginosa
/
Repressor Proteins
/
Bacterial Proteins
/
Gene Expression Regulation, Bacterial
/
Biofilms
Limits:
Humans
Language:
En
Journal:
Microbiology (Reading)
Journal subject:
MICROBIOLOGIA
Year:
2012
Document type:
Article
Affiliation country:
Irlanda