A sexual ornament in chickens is affected by pleiotropic alleles at HAO1 and BMP2, selected during domestication.
PLoS Genet
; 8(8): e1002914, 2012.
Article
in En
| MEDLINE
| ID: mdl-22956912
ABSTRACT
Domestication is one of the strongest forms of short-term, directional selection. Although selection is typically only exerted on one or a few target traits, domestication can lead to numerous changes in many seemingly unrelated phenotypes. It is unknown whether such correlated responses are due to pleiotropy or linkage between separate genetic architectures. Using three separate intercrosses between wild and domestic chickens, a locus affecting comb mass (a sexual ornament in the chicken) and several fitness traits (primarily medullary bone allocation and fecundity) was identified. This locus contains two tightly-linked genes, BMP2 and HAO1, which together produce the range of pleiotropic effects seen. This study demonstrates the importance of pleiotropy (or extremely close linkage) in domestication. The nature of this pleiotropy also provides insights into how this sexual ornament could be maintained in wild populations.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Chickens
/
Comb and Wattles
/
Alcohol Oxidoreductases
/
Bone Morphogenetic Protein 2
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Genetic Pleiotropy
Type of study:
Prognostic_studies
Limits:
Animals
Language:
En
Journal:
PLoS Genet
Journal subject:
GENETICA
Year:
2012
Document type:
Article
Affiliation country:
Suecia
Publication country:
EEUU
/
ESTADOS UNIDOS
/
ESTADOS UNIDOS DA AMERICA
/
EUA
/
UNITED STATES
/
UNITED STATES OF AMERICA
/
US
/
USA