PINCH expression and its clinicopathological significance in gastric adenocarcinoma.
Dis Markers
; 33(4): 171-8, 2012.
Article
in En
| MEDLINE
| ID: mdl-22976000
ABSTRACT
OBJECTIVE:
Particularly interesting new cysteine-histidine rich protein (PINCH) is an important component of the local adhesion complexes and upregulated in several types of malignancies, and involved in the incidence and development of tumours. PINCH expression is also independently correlated with poorer survival in patients with colorectal cancer. However, there is no study of PINCH in gastric cancer, therefore, the aim of this project was to investigate PINCH expression and its clinicopathological significance in gastric adenocarcinoma. PATIENTS ANDMETHODS:
PINCH expression was immunohistochemically examined in normal gastric mucous (n=30) and gastric adenocarcinoma (n=73), from gastric cancer patients.RESULTS:
PINCH expression in the associated-stroma of gastric cancers was heterogeneous, and its positive rate (75%) was higher than that of normal gastric mucosa (43%,
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Adenocarcinoma
/
Gene Expression Regulation, Neoplastic
/
Adaptor Proteins, Signal Transducing
/
LIM Domain Proteins
/
Gastrointestinal Neoplasms
Type of study:
Diagnostic_studies
Limits:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
Dis Markers
Journal subject:
BIOQUIMICA
Year:
2012
Document type:
Article
Affiliation country:
China