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Reaction of human cytochrome P450 3A4 with peroxynitrite: nitrotyrosine formation on the proximal side impairs its interaction with NADPH-cytochrome P450 reductase.
Lin, Hsia-lien; Kenaan, Cesar; Zhang, Haoming; Hollenberg, Paul F.
Affiliation
  • Lin HL; Department of Pharmacology, University of Michigan, 2301 MSRB III, 1150 West Medical Center Drive, Ann Arbor, Michigan 48109-5632, United States.
Chem Res Toxicol ; 25(12): 2642-53, 2012 Dec 17.
Article in En | MEDLINE | ID: mdl-23016756
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Tyrosine / NADPH-Ferrihemoprotein Reductase / Peroxynitrous Acid / Cytochrome P-450 CYP3A Limits: Humans Language: En Journal: Chem Res Toxicol Journal subject: TOXICOLOGIA Year: 2012 Document type: Article Affiliation country: Estados Unidos Country of publication: Estados Unidos
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Tyrosine / NADPH-Ferrihemoprotein Reductase / Peroxynitrous Acid / Cytochrome P-450 CYP3A Limits: Humans Language: En Journal: Chem Res Toxicol Journal subject: TOXICOLOGIA Year: 2012 Document type: Article Affiliation country: Estados Unidos Country of publication: Estados Unidos