Aromatic core extension in the series of N-cyclic bay-substituted perylene G-quadruplex ligands: increased telomere damage, antitumor activity, and strong selectivity for neoplastic over healthy cells.

Franceschin, Marco; Rizzo, Angela; Casagrande, Valentina; Salvati, Erica; Alvino, Antonello; Altieri, Alessandro; Ciammaichella, Alina; Iachettini, Sara; Leonetti, Carlo; Ortaggi, Giancarlo; Porru, Manuela; Bianco, Armandodoriano; Biroccio, Annamaria

Franceschin, Marco; Rizzo, Angela; Casagrande, Valentina; Salvati, Erica; Alvino, Antonello; Altieri, Alessandro; Ciammaichella, Alina; Iachettini, Sara; Leonetti, Carlo; Ortaggi, Giancarlo; Porru, Manuela; Bianco, Armandodoriano; Biroccio, Annamaria.

Affiliation

Franceschin M; Dipartimento di Chimica, Sapienza Università di Roma, P.le.A. Moro 5, 00185 Roma, Italy.

ChemMedChem ; 7(12): 2144-54, 2012 Dec.

Article in En | MEDLINE | ID: mdl-23097341

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Perylene / Polycyclic Compounds / G-Quadruplexes / Antineoplastic Agents Limits: Humans Language: En Journal: ChemMedChem Journal subject: FARMACOLOGIA / QUIMICA Year: 2012 Document type: Article Affiliation country: Italia

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