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Identification of gold nanoparticle-resistant mutants of Saccharomyces cerevisiae suggests a role for respiratory metabolism in mediating toxicity.
Smith, Mark R; Boenzli, Matthew G; Hindagolla, Vihangi; Ding, Jun; Miller, John M; Hutchison, James E; Greenwood, Jeffrey A; Abeliovich, Hagai; Bakalinsky, Alan T.
Affiliation
  • Smith MR; Department of Food Science and Technology, Oregon State University, Corvallis, Oregon, USA.
Appl Environ Microbiol ; 79(2): 728-33, 2013 Jan.
Article in En | MEDLINE | ID: mdl-23144132
ABSTRACT
Positively charged gold nanoparticles (0.8-nm core diameter) reduced yeast survival, but not growth, at a concentration of 10 to 100 µg/ml. Among 17 resistant deletion mutants isolated in a genome-wide screen, highly significant enrichment was observed for respiration-deficient mutants lacking genes encoding proteins associated with the mitochondrion.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Saccharomyces cerevisiae / Metabolic Networks and Pathways / Nanoparticles / Gold Type of study: Diagnostic_studies Language: En Journal: Appl Environ Microbiol Year: 2013 Document type: Article Affiliation country: Estados Unidos
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Saccharomyces cerevisiae / Metabolic Networks and Pathways / Nanoparticles / Gold Type of study: Diagnostic_studies Language: En Journal: Appl Environ Microbiol Year: 2013 Document type: Article Affiliation country: Estados Unidos