Toll-like receptor 5 agonism protects mice from radiation pneumonitis and pulmonary fibrosis.
Asian Pac J Cancer Prev
; 13(9): 4763-7, 2012.
Article
in En
| MEDLINE
| ID: mdl-23167416
ABSTRACT
Radiation pneumonitis and pulmonary fibrosis are the main complications with radiotherapy for thoracic neoplasms, directly limiting the efficient dose in clinical application and currently there are few medicines that effectively function as radioprotectants. However, a TLR5 agonist, CBLB502, was confirmed to have protective efficacy against hematopoietic and gastrointestinal radiation syndromes in mice and primates. This study points to a new direction for protection against thoracic radiation-induced pulmonary syndromes and skin injury by CBLB502. We utilized the TUNEL assay, pathological analysis and immunohistochemistry to obtain evidence that CBLB502 could alleviate the occurrence of radiation pneumonitis and pulmonary fibrosis as well as radiation- induced skin injury. It may thus play a promising role in facilitating clinical radiotherapy of thoracic neoplasms.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Peptides
/
Pulmonary Fibrosis
/
Radiation Injuries, Experimental
/
Radiation-Protective Agents
/
Radiation Pneumonitis
/
Toll-Like Receptor 5
Type of study:
Etiology_studies
Limits:
Animals
Language:
En
Journal:
Asian Pac J Cancer Prev
Journal subject:
NEOPLASIAS
Year:
2012
Document type:
Article
Affiliation country:
China