Sirolimus therapy may cause cardiac tamponade.
Transpl Int
; 26(2): e4-7, 2013 Feb.
Article
in En
| MEDLINE
| ID: mdl-23189945
ABSTRACT
The side-effects associated with the immunosuppressive drug sirolimus are numerous and constitute a major limitation for its use in renal transplantation. In this study, we describe two cases of renal transplant recipients treated with sirolimus who developed pericardial tamponade associated with interstitial pneumonia, proteinuria, microcytic anemia and, in one case, lymphocytic meningitidis. An extensive search for infectious agents was negative, and all symptoms disappeared after sirolimus interruption. Therefore, this case demonstrates for the first time that sirolimus can cause pericardial tamponade as well as lymphocytic meningitidis.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Cardiac Tamponade
/
Kidney Transplantation
/
Sirolimus
/
Immunosuppressive Agents
Type of study:
Etiology_studies
Limits:
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
Transpl Int
Journal subject:
TRANSPLANTE
Year:
2013
Document type:
Article
Affiliation country:
Francia