CTCFBSDB 2.0: a database for CTCF-binding sites and genome organization.
Nucleic Acids Res
; 41(Database issue): D188-94, 2013 Jan.
Article
in En
| MEDLINE
| ID: mdl-23193294
ABSTRACT
CTCF is a highly conserved transcriptional regulator protein that performs diverse functions such as regulating gene expression and organizing the 3D structure of the genome. Here, we describe recent updates to a database of CTCF-binding sites, CTCFBSDB (http//insulatordb.uthsc.edu/), which now contains almost 15 million CTCF-binding sequences in 10 species. Since the original publication of the database, studies of the 3D structure of the genome, such as those provided by Hi-C experiments, have suggested that CTCF plays an important role in mediating intra- and inter-chromosomal interactions. To reflect this important progress, we have integrated CTCF-binding sites with genomic topological domains defined using Hi-C data. Additionally, the updated database includes new features enabled by new CTCF-binding site data, including binding site occupancy and the ability to visualize overlapping CTCF-binding sites determined in separate experiments.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Repressor Proteins
/
Databases, Genetic
Limits:
Animals
/
Humans
Language:
En
Journal:
Nucleic Acids Res
Year:
2013
Document type:
Article
Affiliation country:
Estados Unidos