Computational modeling of microabscess formation.
Comput Math Methods Med
; 2012: 736394, 2012.
Article
in En
| MEDLINE
| ID: mdl-23197993
ABSTRACT
Bacterial infections can be of two types acute or chronic. The chronic bacterial infections are characterized by being a large bacterial infection and/or an infection where the bacteria grows rapidly. In these cases, the immune response is not capable of completely eliminating the infection which may lead to the formation of a pattern known as microabscess (or abscess). The microabscess is characterized by an area comprising fluids, bacteria, immune cells (mainly neutrophils), and many types of dead cells. This distinct pattern of formation can only be numerically reproduced and studied by models that capture the spatiotemporal dynamics of the human immune system (HIS). In this context, our work aims to develop and implement an initial computational model to study the process of microabscess formation during a bacterial infection.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Abscess
Type of study:
Prognostic_studies
Limits:
Humans
Language:
En
Journal:
Comput Math Methods Med
Journal subject:
INFORMATICA MEDICA
Year:
2012
Document type:
Article
Affiliation country:
Brasil