The use of mannitol in partial and live donor nephrectomy: an international survey.
World J Urol
; 31(4): 977-82, 2013 Aug.
Article
in En
| MEDLINE
| ID: mdl-23242033
ABSTRACT
PURPOSE:
Animal studies have shown the potential benefits of mannitol as renoprotective during warm ischemia; it may have antioxidant and anti-inflammatory properties and is sometimes used during partial nephrectomy (PN) and live donor nephrectomy (LDN). Despite this, a prospective study on mannitol has never been performed. The aim of this study is to document patterns of mannitol use during PN and LDN. MATERIALS ANDMETHODS:
A survey on the use of mannitol during PN and LDN was sent to 92 high surgical volume urological centers. Questions included use of mannitol, indications for use, physician responsible for administration, dosage, timing and other renoprotective measures.RESULTS:
Mannitol was used in 78 and 64 % of centers performing PN and LDN, respectively. The indication for use was as antioxidant (21 %), as diuretic (5 %) and as a combination of the two (74 %). For PN, the most common dosages were 12.5 g (30 %) and 25 g (49 %). For LDN, the most common doses were 12.5 g (36.3 %) and 25 g (63.7 %). Overall, 83 % of centers utilized mannitol, and two (percent or centers??) utilized furosemide for renoprotection.CONCLUSIONS:
A large majority of high-volume centers performing PN and LDN use mannitol for renoprotection. Since there are no data proving its value nor standardized indication and usage, this survey may provide information for a randomized prospective study.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Kidney Transplantation
/
Living Donors
/
Kidney
/
Mannitol
/
Nephrectomy
Type of study:
Clinical_trials
/
Observational_studies
Limits:
Humans
Language:
En
Journal:
World J Urol
Year:
2013
Document type:
Article
Affiliation country:
España