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Genetic variants in genes related to lipid metabolism and atherosclerosis, dyslipidemia and atorvastatin response.
Rodrigues, A C; Sobrino, B; Genvigir, F D V; Willrich, M A V; Arazi, S S; Dorea, E L; Bernik, M M S; Bertolami, M; Faludi, A A; Brion, M J; Carracedo, A; Hirata, M H; Hirata, R D C.
Affiliation
  • Rodrigues AC; Faculdade de Ciências Farmacêuticas, USP, São Paulo, SP, Brazil. alice-rodrigues@usp.br
Clin Chim Acta ; 417: 8-11, 2013 Feb 18.
Article in En | MEDLINE | ID: mdl-23247049
OBJECTIVE: Using candidate gene approach, we have investigated the effect of single nucleotide polymorphism (SNP) in genes related to lipid metabolism and atherosclerosis on dyslipidemia and atorvastatin response. METHODS: The study included 157 patients treated with atorvastatin and 145 controls. Genomic DNA was isolated and genotyped using SNPlex technology. RESULTS: Allele and genotype disease association test revealed that APOB rs693 (OR: 2.2 [1.5-3.2], p=0.0001) and CD36 rs1984112 (OR: 3.7 [1.9-7.0], p=0.0002) SNPs were independent risk factors for hypercholesterolemia. Only APOB rs693 T variant allele was associated with increased LDL cholesterol levels (>160mg/dL). After atorvastatin treatment (10mg/day/4weeks), LIPC -514T allele was positively associated with LDL cholesterol reduction. CONCLUSION: The current study reinforces the current knowledge that carrying APOB rs693 is an independent risk factor for dyslipidemia and higher LDL levels. Furthermore, we found that a variant of CD36 was associated with dyslipidemia as a risk (rs1984112) factor. Finally, atorvastatin response could be predicted by LIPC -514C>T SNP and physical activity. In conclusion, our data evidences the contribution of genetic markers and their interaction with environmental factor in the variability of statin response.
Subject(s)

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyrroles / Polymorphism, Single Nucleotide / Atherosclerosis / Dyslipidemias / Lipid Metabolism / Heptanoic Acids Type of study: Prognostic_studies / Risk_factors_studies Limits: Female / Humans / Male / Middle aged Language: En Journal: Clin Chim Acta Year: 2013 Document type: Article Affiliation country: Brasil Country of publication: Países Bajos

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyrroles / Polymorphism, Single Nucleotide / Atherosclerosis / Dyslipidemias / Lipid Metabolism / Heptanoic Acids Type of study: Prognostic_studies / Risk_factors_studies Limits: Female / Humans / Male / Middle aged Language: En Journal: Clin Chim Acta Year: 2013 Document type: Article Affiliation country: Brasil Country of publication: Países Bajos