Sex hormones and HCV: an unresolved mystery.
Expert Rev Gastroenterol Hepatol
; 7(1): 69-75, 2013 Jan.
Article
in En
| MEDLINE
| ID: mdl-23265151
ABSTRACT
The biological differences between males and females advocate the ultimate need for gender-specific medicine. The variation in response to viral infection as well as therapy among different genders makes it very intriguing to reveal the responsible factors for causing this discrepancy. HCV is one of the most noxious infectious diseases, however the impact of gender on the response to HCV has received negligible attention in the literature. The controversial studies concerning the effect of gender on the outcome of interferon-based therapy urge a need to judge the gender discrepancy in host factors responsible for both interferon release and action. The main aim of this review is to disentangle the interplay between sex hormones and several viral and host factors responsible for viral clearance in an attempt to clarify the role of gender in modulating the response to HCV as well as interferon-based therapy.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Gonadal Steroid Hormones
/
Hepatitis C
/
Hepacivirus
/
Health Status Disparities
Type of study:
Diagnostic_studies
Aspects:
Determinantes_sociais_saude
/
Equity_inequality
/
Patient_preference
Limits:
Animals
/
Female
/
Humans
/
Male
Language:
En
Journal:
Expert Rev Gastroenterol Hepatol
Journal subject:
GASTROENTEROLOGIA
Year:
2013
Document type:
Article
Affiliation country:
Egipto