Chromatin organization: form to function.
Curr Opin Genet Dev
; 23(2): 185-90, 2013 Apr.
Article
in En
| MEDLINE
| ID: mdl-23274160
ABSTRACT
Recent developments in technology have made it possible to create high resolution genome-wide maps of histone marks, DNA binding proteins and physical interactions along genomic regions. Chromatin features are found together in different combinations, dividing the genome up into domains with distinct functional properties. Microscopy and chromatin conformation capture techniques have shown that the 3D structure of chromosomes is constrained by nuclear features and functional links between different parts of chromatin. These results provide insights about the 3D and domain organization of the genome and their connection to gene regulation and other nuclear functions.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Chromatin
/
Histones
/
Chromosomes
/
Genome
Limits:
Animals
/
Humans
Language:
En
Journal:
Curr Opin Genet Dev
Journal subject:
GENETICA
Year:
2013
Document type:
Article
Affiliation country:
Países Bajos