Antifilarial activity of CGP 20376 against subperiodic Brugia malayi in the leaf-monkey Presbytis cristata.
Trop Med Parasitol
; 41(1): 10-2, 1990 Mar.
Article
in En
| MEDLINE
| ID: mdl-2339241
ABSTRACT
CGP 20376, a 5-methoxyl-6-dithiocarbamic-S- (2-carboxy-ethyl) ester derivative of benzothiazole was evaluated for its antifilarial properties and shown to be extremely effective against subperiodic Brugia malayi in the leaf-monkey, Presbytis cristata at oral doses of 20-100 mg/kg. The compound and/or its metabolites had complete micro- and microfilaricidal activities even when given at a single dose of 20 mg/kg. Lower doses had incomplete filaricidal action.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Thiazoles
/
Elephantiasis, Filarial
/
Filariasis
/
Filaricides
/
Anthelmintics
Limits:
Animals
Language:
En
Journal:
Trop Med Parasitol
Journal subject:
MEDICINA TROPICAL
/
PARASITOLOGIA
Year:
1990
Document type:
Article
Affiliation country:
Malasia